We propose using neural networks for simultaneous detection and localization of multiple sound sources in human-robot interaction. In contrast to conventional signal processing techniques, neural network-based sound source localization methods require fewer strong assumptions about the environment. Previous neural network-based methods have been focusing on localizing a single sound source, which do not extend to multiple sources in terms of detection and localization. In this paper, we thus propose a likelihood-based encoding of the network output, which naturally allows the detection of an arbitrary number of sources. In addition, we investigate the use of sub-band cross-correlation information as features for better localization in sound mixtures, as well as three different network architectures based on different motivations. Experiments on real data recorded from a robot show that our proposed methods significantly outperform the popular spatial spectrum-based approaches.